How vitamin D controls bone mineralization

Nutritional rickets is caused by a vitamin D deficiency, and people figured out two ways to treat it before we even knew what vitamin D was.

Research:

• “Oldest UK case of rickets in Neolithic Tiree skeleton.” 9/10/2015. https://www.bbc.com/news/uk-scotland-glasgow-west-34208976
• Carpenter, Kenneth J. “Harriette Chick and the Problem of Rickets.” The Journal of Nutrition, Volume 138, Issue 5, 827 – 832
• Chesney, Russell W. “New thoughts concerning the epidemic of rickets: was the role of alum overlooked?.” Pediatric Nephrology. (2012) 27:3–6. DOI 10.1007/s00467-011-2004-9.
• Craig, Wallace and Morris Belkin. “The Prevention and Cure of Rickets.” The Scientific Monthly , May, 1925, Vol. 20, No. 5 (May, 1925). Via JSTOR. https://www.jstor.org/stable/7260
• Davidson, Tish. "Rickets." The Gale Encyclopedia of Medicine, edited by Jacqueline L. Longe, 6th ed., vol. 7, Gale, 2020, pp. 4485-4487. Gale OneFile: Health and Medicine, link.gale.com/apps/doc/CX7986601644/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=811f7e02. Accessed 7 Jan. 2026.
• Friedman, Aaron. “A brief history of rickets.” Pediatric Nephrology (2020) 35:1835–1841. https://doi.org/10.1007/s00467-019-04366-9
• Hawkes, Colin P, and Michael A Levine. “A painting of the Christ Child with bowed legs: Rickets in the Renaissance.” American journal of medical genetics. Part C, Seminars in medical genetics vol. 187,2 (2021): 216-218. doi:10.1002/ajmg.c.31894
• Ihde, Aaron J. “Studies on the History of Rickets. I: Recognition of Rickets as a Deficiency Disease.” Pharmacy in History, 1974, Vol. 16, No. 3 (1974). https://www.jstor.org/stable/41108858
• Ihde, Aaron J. “Studies on the History of Rickets. II : The Roles of Cod Liver Oil and Light.” Pharmacy in History, 1975, Vol. 17, No. 1 (1975). https://www.jstor.org/stable/41108885
• Newton, Gil. “Diagnosing Rickets in Early Modern England: Statistical Evidence and Social Response.” Social History of Medicine Vol. 35, No. 2 pp. 566–588. https://academic.oup.com/shm/article/35/2/566/6381535
• O'Riordan, Jeffrey L H, and Olav L M Bijvoet. “Rickets before the discovery of vitamin D.” BoneKEy reports vol. 3 478. 8 Jan. 2014, doi:10.1038/bonekey.2013.212.
• Palm, T. “Etiology of Rickets.” Br Med J 1888; 2 doi: https://doi.org/10.1136/bmj.2.1457.1247 (Published 01 December 1888)
• Rajakumar, Kumaravel and Stephen B. Thomas. “Reemerging Nutritional Rickets: A Historical Perspective.” Arch Pediatr Adolesc Med. Published Online: April 2005 2005;159;(4):335-341. doi:10.1001/archpedi.159.4.335
• Swinburne, Layinka M. “Rickets and the Fairfax family receipt books.” Journal of the Royal Society of Medicine. Vol. 99. August 2006.
• Tait, H. P.. “Daniel Whistler and His Contribution to Pædiatrics.” Edinburgh Medical Journal vol. 53,6 (1946): 325–330.
• Warren, Christian. “No Magic Bolus: What the History of Rickets and Vitamin D Can Teach Us About Setting Standards.” Journal of Adolescent Health. 66 (2020) 379e380. https://www.jahonline.org/article/S1054-139X(20)30038-0/pdf
• Wheeler, Benjamin J et al. “A Brief History of Nutritional Rickets.” Frontiers in endocrinology vol. 10 795. 14 Nov. 2019, doi:10.3389/fendo.2019.00795
• World Health Organization. “The Magnitude and Distribution of Nutritoinal Rickets: Disease Burden in Infants, Children, and Adolescents.” 2019. Via JSTOR. https://www.jstor.org/stable/resrep27899.7
• Zhang, M., Shen, F., Petryk, A., Tang, J., Chen, X., & Sergi, C. (2016). “English Disease”: Historical Notes on Rickets, the Bone–Lung Link and Child Neglect Issues. Nutrients, 8(11), 722. https://doi.org/10.3390/nu8110722

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