Breast Cancer - Is TDXD an Absolute Contraindication?

Most breast cancer patients don't have pre-existing lung problems. So again, how does the trial handle prior COPD and other cardiopulmonary problems? And clinically, what do you do when you want to use? You have a hurt to mutant situation, but yet the patient's got maybe even symptomatic COPD. Yeah. The same could apply with IO checkpoint, which can cause pneumonitis in a fair number of patients. But I don't see this as an absolute contraindication,. particularly coming from a lung cancer perspective where they all have some lung condition.