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Gain of Function Research
The original h five n one gain of function research was the roughest of prototypes for what's sible now for a much, much larger group of people. This makes any clouded understanding of the human transmissability of those original viruses kind of immaterial. The first reason is that it is enormously possible that nature will never get around to creating the ghastly things that we invent where they gain of function research. But an even better reason to never do any gain of function research is as you pointed out, no laboratory of any level of secure can be wholly immune from leakages and accidents.