In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.

Thank you to our sponsors:

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Our Patreon page: https://www.patreon.com/davidsinclair

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Matthew LaPlante's Social:

Twitter

Timestamps:

(00:00:00) Kicking Off Episode Five: Interventions on the Cutting Edge

(00:02:39) Expressing Gratitude to the Sponsors

(00:05:28) Testosterone Replacement Therapy

(00:10:09) Human Growth Hormone

(00:13:56) Peptide Supplementation and Regenerative Signaling

(00:18:11) MOTS-c, Humanin, and Other Peptides

(00:25:05) Exosome Therapy

(00:31:56) A Primer on Stem Cells and Yamanaka Factors

(00:37:59) Stem Cell Aging and Cord Blood Banking

(00:41:42) The Therapeutic Potential of Stem Cells

(00:43:37) Cellular Reprogramming

(00:51:35) Resetting the Aging Clock

(00:56:50) The Future Looks Bright

(00:58:15) Next Week’s Episode: External Aging

(00:58:36) Subscription and Support Options

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

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