#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin
The Peter Attia Drive
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The Obese Mouse
The first evidence in this regard came from experiments that were done by an investigator at the jackson laboratories in maine named douglas coleman. He was a biochemist, physiologist who was interested in some of the rare mouse mutations that led to very severe obesity. These animals had what you might call trifecta for obesity. They ate more, spent less, and whatever they stored was preferentially stored as fat. And these were fascinating animals. I mean, people tried for many years to figure out what was wrong with them,. but nothing about their physiology necessarily pointed to what the primar mechanism was.
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