The Relationship Between Preclinical Data and Patient Outcomes

The preclinical data are very clear in your lab and Bill Craig's lab. Protein binding, getting free drug concentrations is exceptionally difficult for those of us that develop assays. And then I think you outlined all the reasons why patients are just hard. You know, when we measure these things clinically, the best thing we can do is look at something like an Apache score,. But that composite number really doesn't capture the patient as well as even the clinician can explain to you.