Caloriticalin Mutation Positive Patients

Anti-mutant caloritical antibody would inhibit the activation of or the mineralization of the receptors that is necessary to slow dying off of malignant cells. That has been done in mice and we hope that we have that study open in people so by the end of this year as a first ever caloriticalsin antibody driven study for specific mutation positive patients. It's safe you can start treating perhaps earlier phase patients to to uh intervene early and in that setting perhaps eliminate disease prevent progression.