The Paradox of Diuretics in Polycystic Kidney Disease

There is actually emergent data using thiazides in addition to the Vaptan to counteract this polyurea. So it kind of makes sense, but There's been a lot of Interesting experiments that kind of contradict that so there was one that I thought was really cool It was in the late 90s was done in Denmark and they basically gave them they metered how much salt they put out after inducing di and then they gave them back that salt. And they found that restoring their GFR didn't slow down the poly Didn't decrease the effectiveness of slowing down the polyurea or anything like that.