Factor H variants in paroxysmal nocturnal hemoglobinuria, the role of factor XII in SCD-related thrombosis, and clinical features of therapy-related NPM1-mutated AML
Blood Podcast
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The Effects of Therapy-Related NPM1 Mutated AML on Survival
Genomic DNA was analyzed from a total of 107 therapy-related NPM1-mutated AML cases. TP53 and PPM1-D genes, which are typically mutated in myeloid neoplasms, were predominantly wild-type in patients with NPM1 mutations. A normal carotype was found in 88% of therapy- related NPM 1-mutatedAMLs.
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