Use of Run-in Periods in Randomized Trials With Dr Armitage
JAMAevidence JAMA Guide to Statistics and Methods
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Run-in Periods Are Underutilized in Clinical Trials
Dr. Jane Armitage: Run-ins are underutilized in clinical trials. A patient stopping being adherent after randomization has a similar impact as needing two more patients to be recruited, she says. Dr. Robert Gollib: For long-term trials, including a run-in is usually a better option than not doing so.
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