Up to the nineteenth century, scientists were very confident of completing their fields. In fact, one mathematician had a programme to complete mathematics. And that was frustrated because of godel who came along and showed that it can't be done. Did did expected complete ness, absoluteness,. not uncertainty, certainty, but the deeper understanding of nature became relativity o uncertainty.
Inspired by the 15th chapter of the Ashtavakra Gita, Swami Sarvapriyananda gives a discourse on the nature of the Self.