Your study or at least the one that I saw in cell that was male subjects. Have you given any thoughts as to whether these protocols and I appreciate they just may not be evidence but do you think for any reason the protocol or approach to temperature or duration would be different for a female versus a male? Yeah I'm glad that you asked me this question actually because I just want to reflect on that a bitBecause it's something that people have asked me a lot and some actually get a little bit um yeah they want to discuss at least why I recruited only men for my study.

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