Doe Act Compared to Warfarin?

In Canada or you know, world there are four clinically available direct oral anticoagulants. Each of them have a pivotal phase three randomized control trial comparing its to warfarin and published in the New England Journal of Medicine. These agents are just as safe as warfarin because when they look at major bleeding risk. The main contraindications nowadays with the work use are for patients and mechanical heart valves.