Beta 2 is located on the muscles of the airways. It inhibits them from contracting, so they dilate. If you throw a beta blocker at both of these, throw a beta blockers at beta 1, the heart's going to relax. So people who arguably have respiratory challenges, like asthma, or let's say unstable asthma, and COPD, these drugs, non-selectives would be a condition, no, it's a caution against.