The Effects of the Ibrutinib Trial on Progression-Free Survival

Is there anything about the trial that may have sort of led to these data, but not really reflecting an accurate difference? I do think these drugs are better tolerated. Is it enough to sway 15% plus progression free survival? I'm not so sure that the arms were pretty well balanced. And you know, there is the other side of this that the drug may in fact have this PK, you know, data behind it to suggest it might just be a more effective drug.