Unraveling Antibiotic Resistance Mechanisms

This chapter explores the intricate world of antibiotic resistance, with a specific focus on efflux pumps and their role in Gram-negative bacteria. The discussion covers various resistance mechanisms, including pore channel mutations and their implications for treating infections, particularly with beta-lactam antibiotics. It also emphasizes the challenges clinical labs face in predicting resistance phenotypes and the importance of understanding these mechanisms for optimizing antibiotic efficacy.