Whether it's via TikTok or the morning news, you’ve probably heard the recent hype (and hand-wringing) about new prescription weight-loss medications with names like Ozempic, Wegovy, and Mounjaro. These drugs were originally developed to treat diabetes, but, in some patients, they've had a surprising side effect: they seem to silence feelings of hunger, leading to significant weight loss. This episode, Gastropod goes behind the headlines to ask: What is hunger, anyway? And what do we know about how to switch it on or off? Join us for a story that involves lizard saliva, synthesizer shopping, and a disorder that can lead people to eat until their stomachs burst, as we explore these universal feelings—hunger and fullness—that shape our lives, and bookend every meal.

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