In this episode we discuss:
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Whether David Perlmutter and Rick Johnson are right about fructose and uric acid being drivers of poor metabolic health
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Why fructose will not cause ATP depletion when it’s consumed in normal contexts
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Why fructose and uric acid are not the drivers of metabolic syndrome and degenerative conditions
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The protective effects of fructose in the liver
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Why it’s extremely important to consider the different contexts in which uric acid is produced
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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-84-fructose-and-uric-acid-are-david-perlmutter-and-rick-johnson-wrong-part-1/
Timestamps:
3:56 – why we’re discussing fructose and uric acid
8:38 – the general argument that fructose consumption drives uric acid production and that this is responsible for disease and degeneration
14:48 – our general counterargument that fructose consumption does not drive disease and degeneration via uric acid production
18:41 – whether fructose depletes ATP in the liver
30:03 – fructose is extremely protective and generally increases ATP availability in the liver
36:27 – how fructose can increase uric acid via ATP depletion
38:51 – why fructose doesn’t cause ATP depletion and uric acid production unless it’s given in extreme, non-physiologically relevant contexts
1:04:50 – whether uric acid is the driver of metabolic syndrome and many degenerative conditions by driving oxidative stress
1:15:46 – why xanthine oxidase is a major confounding variable to consider when evaluating whether uric acid production is harmful
1:27:02 – whether the activation of AMP deaminase is a reason not to consume fructose
1:27:55 – average fructose intakes are far below the amounts that are typically used in research
