The Role of Proteasome Inhibitors in Multiple Myeloma

Triplet is still preferred in the relapse setting over doublet and there were a lot of landmark studies. Velcade or Bertesumib, which is the V and all the regimens are either IV or sub queue sub queue is preferred. Exasamib has less neuropathy but more GI toxicity in the form of nausea and diarrhea. It also leads to thromosideopenia, GIToxicity, rash, varicella zoster.