#010 Dr. Aubrey de Grey and Dr. Rhonda Patrick Talk Aging
FoundMyFitness
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The Cell Cycle Regulator, ARF P16 in Puree, Is Silent?
The cell cycle regulator ARF P16 in puree is silent, epigenetically silent. If it's not silenced, stem cell stop dividing. And so, you know, you want the stem cell to divide. So there's two answers to that: reprogramming and de-differentiation. The other thing to mention, though, is that if you take a bunch of skin cells from an older person, then there's going to be a spectrum of level of expression of P16. Now, it may be that the process of getting it back to the IPS state will actually be affected by that.
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