Exploring Metformin: Mechanisms and Implications

• The major issues with the SCD-1 theory of obesity

• Why fructose doesn’t drive fat gain or necessarily increase SCD-1

• Why PUFA are harmful even if they decrease SCD-1

• Why fat-burning is not the answer for healthy fat loss

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-48-a-critique-of-the-scd1-theory-of-obesity-the-croissant-diet-part-2/

Timestamps:

3:00 – an introduction to SCD-1 in the context of obesity and lipogenesis

15:46 – SCD-1 in relation to ROS, fat oxidation, and fructose

23:51 – the relationship between PUFA, AMPK, and SCD-1

29:13 – whether the oxidation of saturated fats would decrease SCD-1 by increasing ROS and why this wouldn’t be ideal

44:03 – why the potential for fructose to increase SCD-1 is not a concern

56:29 – why PUFA are harmful even if they decrease SCD-1

1:04:45 – whether SCD-1 is the culprit behind obesity