COPD; Roadside to Resus
The Resus Room
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COPD and CO2 Retention
The Haldane effect relies upon the fact that deoxygenated hemoglobin binds with a much stronger affinity than when it's oxygenated. Patients who have more severe hypoxia are actually at higher risk of developing CO2 retention from uncontrolled oxygen administration. They can't increase their ventilation in those patients to dissociation, which is basically what I've been talking about for the last two minutes. So giving them a lot of oxygen releases CO2 into the bloodstream and then on the other hand gives them respiration so they're not as likely to suffer respiratory failure.
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