The Ecological Assessment of STD in the George Institute

The primary outcome was all cause in hospital mortality since it at 90 days after admission. Secondary endpoints included the intensive care mortality, days alive and free of mechanical ventilator use as well as microbiological secondary outcomes. For the ecological assessment, we modeled specifically the question whether STD was non-inferior to standard care. The cumulative incidence function training there meant cumulative total daily defined doses of antibiotics. To affect an absolute risk reduction of 4.5% or a relative risk reduction of 15.5%, or a number needed to treat of 22, from a baseline mortality of 29%, with 80% power and an alpha of 0.05.