Skeletal Editing Could Help Medical Chemists Screen for Drug-Like Activity

In the past two years, there has been an explosion in the number of papers published relating to 'skeletal editing', a technique that allows chemists to precisely edit a molecule by deleting, adding or swapping single atoms in its core.

Although many of these methods are early in development, researchers hope skeletal editing could revolutionize how organic chemists design molecules, dramatically speeding up the drug-discovery process.

This is an audio version of our Feature: ‘Almost magical’: chemists can now move single atoms in and out of a molecule’s core

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