TWiV 1189: Viruses making waves
This Week in Virology
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Calcium Signaling in Rotavirus Infection
This chapter investigates the role of the NSP4 protein in rotavirus strains of varying virulence and its impact on calcium signaling in infected cells. By using human intestinal organoids, the authors analyze how amino acid changes in NSP4 influence calcium wave induction and immune responses. The findings reveal significant differences in cellular reactions to virulent and attenuated strains, shedding light on viral pathogenesis and potential antiviral strategies.
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