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RNA Profiling and Epigenome Profiling for Alzheimer's Disease
In one year, we basically generated 10 million cells from human brain across a dozen different disorders. And when you look at the average, it washes out some potentially important signal that corresponds to ultimately the disease. We can now look at correlated activity across 2.3 million enhancers and 20,000 genes in each of millions of cells. This is piecing together the regulatory circuitry of every single type of neuron,. Every single type of astrocytes, oligodendrocyte, microglial cell inside the brains of 1,500 individuals.