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31: Do LMAs increase the risk of aspiration compared to ETTs? - Part I of II

Depth of Anesthesia

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The Rule of Three in Medicine

The rule of three states that if a certain event did not occur in a sample with n subjects, then the interval from zero to three over n represents a 95 % confidence interval for the rate of occurrences. To illustrate, suppose a pain relief drug is tested on 15 hundred human subjects and no adverse event is recorded. From this rule of three, we can conclude with 95% confidence that fewer than one person in 500 will experience an adverse event. The rule of three should really only be used when events are independent of each other and when the sample size is greater than 30.

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