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Ep. 35: “Inflammatory Bowel Disease” Featuring Dr. Karen Edelblum

The Immunology Podcast

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The Role of TGF-Pera in CD8 Tissue Residency

RONX3 highly expressed particularly on CD8 resident memory cells. If you knock out RONX3 using CRISPR, that this dramatically reduces the residency of CD8 cells and not so much of CD4 cells. A big part of this reprogramming has to do with increasing the accessibility to genes that respond to TGF-pera signaling. By doing this, TGF-Pera can drive a lot of what I mentioned are the genes that are associated with CD8 tissue residency,.

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