This Best of 2025 episode brings together the most impactful moments from the year - featuring highlights with Dr. William Li, Dr. Stacy Sims, Leslie Kenny, Darren Candow, Mark Sisson, and a solo episode of mine.
Across metabolism, hormones, muscle, longevity and performance, these conversations reveal what actually works for midlife health. You’ll hear why brown fat matters, how women should train and fuel as hormones shift, why muscle is essential for metabolic health, and how walking, sprinting and strength outperform chronic cardio.
If you want a science-backed, no-nonsense snapshot of the ideas that shaped 2025 on the show, this episode connects the dots, and gives you clear, practical takeaways you can apply immediately.
WHAT YOU’LL LEARN
• How brown fat supports metabolism and fat loss
• Why women need different training and fuelling strategies in midlife
• The role of protein and creatine in muscle, energy and recovery
• How autophagy supports immune and cellular health
• Why walking and sprinting beat long-duration cardio for longevity
Timestamps
00:00 Metabolism After 40: Fat, Food & the Real Science of Aging Well
17:53 How Women Should Fuel, Train & Recover for Hormonal Health and Longevity
30:53 Why Creatine Becomes Essential for Women’s Strength, Brain & Daily Function
42:30 The Anti-Aging Pathway Most Women Haven’t Heard About Yet (Spermidine)
48:39 Creatine, Cognition & Energy: A Smarter Approach to Women’s Health
54:48 Walking as Medicine: Longevity, Strength & the Most Natural Form of Fitness
VALUABLE RESOURCES
A BIG thank you to our sponsors who make the show possible:• Ozlo Sleepbuds® – Fall asleep faster and stay asleep longer 👉 https://ozlosleep.com/angela | Use code ANGELA for your exclusive discount.
ABOUT THE GUESTS
Dr. William Li - Physician, scientist and author known for his work on angiogenesis, metabolism and food as medicine.
Dr. Stacy Sims - Exercise physiologist and nutrition scientist, founder of Women Are Not Small Men®.
Leslie Kenny - Founder of Oxford Healthspan and expert in autophagy and immune longevity.
Darren Candow - Professor and researcher specializing in creatine, muscle and bone health.
Mark Sisson - Fitness pioneer and author of Born to Walk, focused on metabolic flexibility and longevity.
Angela Foster - Host and performance health coach specializing in hormones, strength and high-performance living.
