Dopemin is not just a pleasure chemical. It can reinforce aviors without necessarily leading to enjoyment. The more signal you dump into your brain, the more your brain is going to down regulate that signal. If i release a bunch of signal, the receiving nuron is like, hay, i'm getting way too much signal. Anddown regulates the receiving end of the receptor. This principle of physiologic tolerance is very well understood. Ii think alcohol addiction can take anywhere from five days for medical treatment to six or seven months if it's chronic. So what we're trying to do with dopemine detalks is fix that receptor regulation.