Episode 3.1: History of Acute Lymphoblastic Leukemia Treatment and Building the BFM Backbone
WolverHeme Happy Hour
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The Story of Vincristine
The story of vincristine is really interesting. And especially for you, Anthony, because I think this is a this is a Canadian discovery, right? Yes, sir. So essentially two groups sort of independently, one at Eli Lilly, and one these group of Canadians discovered or isolated vincristin from the Madagascar periwinkle or vincarosea. They saw no improvement on blood sugar. But they gave it into repair to nearly to rats. The rats only lived about five days, and they died from diffuse multiple abscesses. That's how we got methotrexate,. We had some single agent responses with nitrogen mustards. And so we've got a
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