Chronic inflammation is a low grade but heightened response that's ongoing from the immune system. Some of these proteins are associated with cellular senescence in tissues, which is a largely dysfunctional state of cells. It could be endothelial cells that will cause ultimately issues in the vascular system or some of these biomarkers cross the blood brain barrier and they go to the brain. They actually disrupt function in the brain and it can also cause cellular death. And so these are associated with Alzheimer's disease in those cases for example.