For many women, what's happening between day 21 and day 28 is really profound physiologically. A very simple and effective way to treat it is with a low dose of progesterone that is administered starting at day 21 to 28. Alternatively, women can stretch that out and take progesterone for the entire 14 days following their ovulation. But again, now that's creating a whole new set of issues around oral contraceptives, which many women simply don't want to do.

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