The Pleasure-Pain Nexus

There's not very good evidence that pot is addictive, but slot machines definitely activate the same brain structures. So I do think it's significant that the heart of this book that Thomas DeQuincy wrote in the 1810s, just basically exactly 200 years ago, and then published in 1821 or 1822,. The two central sections are called the pleasures of opium and the pains of opium. And he really puts together the way that the highs are themselves the problem. Like, he focuses on opium where its vice is a result of its virtue, so to speak.