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Hangovers
It's not alcohol directly, but it's the process of alcohol metabolism and the metabolites themselves that cause a lot of the symptoms. So we can go o some specific examples if you want to. But that's really interesting, because one of the ways i remember hearing hangovers described is sort of the result of stealing happiness from to morrow. Same as with cofactors. That's exactly what it is. You're using up your bodies an ad plus, which is a happiness.