The Compounding Effect of Inflammation on Insulin Resistance

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There is an argument to say that you don't have to be overweight to experience the same issues with insulin resistance. You can be a thin person, healthy looking habitus and still have insulin resistance. Chronic inflammation conversants in some resistance, it's not generally accepted to be the primary target for addressing insulin resistance in things like type 2 diabetes. Although I think if you were to improve inflammation, whether it be through diet or exercise, you can get to the root cause of metabolic syndrome.

In today’s solo episode and I’ll be talking about insulin resistance, how this impacts your risk of disease and why insulin resistance could drive many chronic conditions and why certain lifestyle measures work for improving metabolic health.

By the end of the episode you will understand:

The relationship between IR and disease

The importance of sugar balance in the body

What insulin is and how insulin works

What happens when we become resistant to insulin

What are the causes of IR

What we can do to become more insulin sensitive and ultimately prevent disease

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References:

4 grams of glucose - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636990/

IR Overview - https://www.ncbi.nlm.nih.gov/books/NBK507839/

Insulin resistance Mechanisms - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831809/

Insulin resistance, genes and mitochondria - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341556/

Obesity Insulin and cancer - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214048/

Insulin resistance from euglycaemic clamps - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379600/

Sleep debt and Insulin resistance - https://pubmed.ncbi.nlm.nih.gov/10543671/

Increased snacking with poor sleep - https://pubmed.ncbi.nlm.nih.gov/19056602/