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#71 – This is a Potential Breakup Song: Controversies in the Management of Infective Endocarditis

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CHAPTER

Refampen for Staph Forase Bacteria

When the patients that received any combination of beta lactam or vancomycin with or without amineglicoside and with or without Refampen were compared to those that only got monotherapy, the combination groups were about six times more likely to be culture negative. But this study did not have any patient related outcomes that were reported,. nothing about treatment related adverse events or even if the patient's lived or died. And so given its retrospective nature, I suspect that there's numerable uncontrolled confounders in the study which makes it difficult to extrapolate into clinical care.

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