Is Detargeting a Chemotherapeutic Drug a Problem?

There's a number of chemical strategies starting with what people did with peg. Different groups are working on other kinds of things like zwitterionic polymers or other materials that Katie mentioned. And then when you think about nucleic acid delivery, there's so many interesting things that you can do with the design of the nucleic acid. So I think that I think you really have to look at these things on a case by case basis.