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The Importance of Variance in Self Experiments
When you look at something like an antidepressant, they're measuring the average effect. But high variance things actually can be very appealing as long as there's not too much tail rest. So it is worth experimenting with something that might benefit you for many decades. And even if you think it has a relatively low likelihood of working, so long as there isn't a risk of persistent negative effects from trying it.