Endotoxin (LPS) raises methylglyoxal and impairs glyoxalase activity

• How glucose and insulin decrease glycation

• Why ketogenic diets can be worse than high-carb diets when it comes to AGE formation

• How autophagy helps to clear AGEs, but increasing autophagy is not the answer

• The true primary drivers of AGE accumulation

• The best diet and supplements for minimizing glycation

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Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/

Timestamps:

0:00 – intro 

0:57 – how glycation products are detoxified and cleared from the body 

4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes 

7:56 – the benefits of carbohydrates for the detoxification of glycation products 

10:42 – the benefits of insulin for the detoxification of glycation products 

12:45 – how AGEs are cleared 

14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs 

19:09 – autophagy can drive disease 

20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed 

24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress 

26:54 – carbohydrates do NOT inhibit autophagy 

29:18 – adequate thyroid hormone supports proper autophagy 

30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system) 

32:56 – do high-carb diets actually impair metabolism and insulin sensitivity 

35:26 – is fructose really worse for blood sugar regulation and glycation? 

37:16 – are low-carb or ketogenic diets the solution to reduce glycation? 

40:32 – increased glycation and oxidative stress on ketogenic diets 

44:09 –low-carb diets don’t prevent glucose exposure 

47:56 – there are still considerable insulin and glucose excursions on low-carb diets 

50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism 

51:52 –the main driver of AGE formation and impaired AGE clearance 

53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs 

56:27 –endotoxin as a driver of glycation and increased AGE production 

58:12 – hypothyroidism as a driver of glycation and AGE accumulation 

59:37 – dietary solutions for reducing glycation and AGEs 

1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products 

1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs 

1:07:33 – iron as a double-edged sword for oxidative stress