It's the first Manchester derby of the new season and, coming quite early in proceedings, there are lots of interesting question marks hanging over both teams.
Firstly, there's the issue of form and fitness: there was relatively little action on the international front for the two squads but there are a couple of fresh injury concerns.
Then, there's the tactical battle. Ruben Amorim has fared well against Pep Guardiola so far in his managerial career; his Manchester United first team is still a "work in progress". but there are reasons to be optimistic about the match-up this time as well.
And, of course, there's the question of goalkeepers. Both sides signed a new 'keeper late in the transfer window, so there could potentially be debutants lining up behind either defence. Will Amorim stick with Bayindir or throw Lammens in at the deepest of deep ends, and has Donnarumma had enough training time to do himself justice?
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