The Effects of Thiazides on Heart Failure

The Channelers went where no nephrology podcasters have gone before, recording in front of a live audience at the National Kidney Foundation Clinical Meeting in Austin. We had all eight Channelers doing a live podcast.

We did a Freely Filtered-inspired draft of the best diuretics.

The draft order:

Leticia Rolon

Anna Gaddy

Joel Topf

Roger Rodby

Josh Waitzman

Amy Yau

JC Velez

And Melanie Hoenig

References

JC

Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease

Intravenous conivaptan for the treatment of hyponatraemia caused by the syndrome of inappropriate secretion of antidiuretic hormone in hospitalized patients: a single-centre experience

Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan

Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia

Josh

Review on amiloride development https://pubmed.ncbi.nlm.nih.gov/7039345/

Toad bladder: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351665/

Amiloride derivatives that inhibit flagella: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544414/

Amiloride as taste sensor: https://www.science.org/doi/10.1126/science.6691151

Batlle on diabetes Insipidus: https://www.nejm.org/doi/full/10.1056/NEJM198502143120705?query=recirc_curatedRelated_article

Amiloride + ddavp for DI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518801/

Amy

Treatment of refractory congestive heart failure and normokalemic hypochloremic alkalosis with acetazolamide and spironolactone.

Acetazolamide reversibly inhibits water conduction by aquaporin-4

Inhibition of Human Aquaporin-1 Water Channel Activity by Carbonic Anhydrase Inhibitors

Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus

Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus

In Vivo Antibacterial Activity of Acetazolamide

Roger

50th anniversary of aldosterone

Joel

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial

Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)

Empagliflozin and Heart failure: Diuretic and Cardiorenal Effects

Anna

Clinical Results of Treatment of Diabetes Insipidus with Drugs of the Chlorothiazide Series

Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride

Influence of renal nerves and sodium balance on the acute antidiuretic effect of bendroflumethiazide in rats with diabetes insipidus

Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and epithelial sodium channel

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic

Walsh AC, Moyes A. Intractable Congestive Heart Failure Successfully Treated With Southey Tubes. Can Med Assoc J. 1964 Jun 13;90(24):1375-6.

Godwin TF, Gunton RW. Clinical trial of a new diuretic, furosemide: comparison with hydrochlorothiazide and mercaptomerin. Can Med Assoc J. 1965 Dec 18;93(25):1296-300.

Gerber JG. Role of prostaglandins in the hemodynamic and tubular effects of furosemide. Fed Proc. 1983 Apr;42(6):1707-10.

Schlatter E, Salomonsson M, Persson AE, Greger R. Macula densa cells sense luminal NaCl concentration via furosemide sensitive Na+2Cl-K+ cotransport. Pflugers Arch. 1989 Jul;414(3):286-90. doi: 10.1007/BF00584628.