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Ep. 39: “Extracellular Nucleotides” Featuring Dr. Henrique Borges da Silva

The Immunology Podcast

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ATP and TCF Expression in CD8 Cells

The ATP gets out there and it being important for CD8 cells. What does this ATP do to CD8 cells? Well, traditionally what we know about picture X7 is that it is an IO channel. It induces calcium flux and in some cases potassium reflux. And if you block somehow or if you go on picture X7 knockouts and you forcefully increase interstellar calcium levels, you'll kind of rescue the phenotype of picture X7 deficiency cells. But how does this affect TCF expression, TCF7 expression is something that we still try to understand. Part of it seems to be related to alterations to the immune metabolism or the cellular metabolism of these cells. That sounds like a reasonable

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