Safety: overcorrection and ODS frequency

The Filtrate

Joel Topf kidneyboy.bsky.social

Swapnil Hiremath @hswapnil.medsky.social

Pedro Teixeira @nephcrit.bsky.social

Special Guests

Ewout J. Hoorn, Professor of Medicine Erasmus MC, Netherlands. One of the primary authors.

Harish Seethapathy, Assistant physician at Massachusetts General Hospital

Editing

Vipin Verghese

The Kidney Connection written and performed by Timothy Yau

Show Notes

A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients in NEJM Evidence, in PubMed, in NephJC

Seethapathy: Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis in NEJM Evidence

MacMillan: Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia in NEJM Evidence

SALSA: Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial in JAMA Internal Medicine

SALT 1 and 2: Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia in NEJM

Hyponatremia registry: Current treatment practice and outcomes. Report of the hyponatremia registry in Kidney International

The Richard Sterns’ article on the lower mortality with more severe hyponatremia: Mortality and Serum Sodium: Do Patients Die from or with Hyponatremia? in CJASN

The European Hyponatremia Guidelines: Clinical practice guideline on diagnosis and treatment of hyponatraemia in The European Journal of Endocrinology

The American Hyponatremia Guidelines: Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations in American Journal of Medicine

Treating hyponatremia: damned if we do and damned if we don't by Tom Berl in Kidney International

Prospective (clamp) versus reactive (rescue) DDAVP in hyponatremia: Safety and efficacy of proactive versus reactive administration of desmopressin in severe symptomatic hyponatremia: a randomized controlled trial in Nature Scientific Reports and as covered in PBFluids

Helbert Rondon’s RCT of urea Urea for Chronic Hyponatremia on ClinicalTrials.gov

Tubular Secretions

Swapnil: Catfishing on CatNet: A Novel by Naomi Kritzer (Amazon)

Harish: Disney Cruise

Edward: Flesh: A Novel (Booker Prize Winner) by David Szalay (Amazon)

Pedro: Scrubs reboot (IMDB)

Joel: KIDNEYcon