2min chapter

JAMA Clinical Reviews cover image

Monoclonal Antibodies Targeting Amyloid for Alzheimer Disease

JAMA Clinical Reviews

CHAPTER

The Trial of Monoclonal Antibodies

The Trailblazer All2 study titrated the duration of treatment to PET scans. Amyloid PET scans were conducted at 24 weeks and again at 52 weeks. If patients had actually demonstrated that amyloid plaque had been cleared on the PET scan, they were transitioned from active treatment to placebo.

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