The Role of Reductases in the Regulation of Free Cortisol and Cortisone

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A Dutch test is a snapshot of how much free cortisol exists, how much free cortisone exists. And equally importantly, how much of their metabolites or breakdown products exist. We basically have some enzymes that will turn cortisol into these and cortisone into this. inflammation, obesity, and factors that are generally associated with poor health accelerate that conversion.

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In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options for the treatment of hormone deficiencies. In addition, Peter delves into hormone replacement therapy (HRT), providing nuanced insights into its appropriate usage and the clinical approach he adopts when working with patients.

Peter supplements these explanations with whiteboard illustrations. For a more complete understanding, we highly recommend watching these videos over just listening. The videos can be found on our YouTube channel or on the show notes page.

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