All human behavior is spurred by the desire to escape discomfort. Even the pursuit of pleasurable sensations are themselves psychologically destabilizing. In fact, the brain spurs us to action by creating this discomfort that gets us to act. If you're hungry, you feel hunger pang so you eat. And if you're stuffed, you at too much. So those are physiological ses to discomfort. It's pretty common sense, right?

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