Is There a Relationship Between Structure and Function?

Do we really understand how the changes in the 3D organization can relate to other mechanisms of gene regulation and gene expression? Can you talk a bit about that? So in a recent manuscript that we published where we looked at the topology in terminally differentiated cells in the brain. Some genes, if they are immensely active, you might see them completely de-condensing. Even as all of us also shown this recently in different terminally differentiate cells by imaging. But in the same system, in the same brain cells, you can see a short gene like each year when become more contacting,. More within a path when it's more highly expressed. The relationship between structure and function depends on the