Matt Clifford is a co-founder of Entrepreneur First and leads their AI efforts, as well as chair of ARIA, the UK’s Advanced Research and Invention Agency. We talk about EF, talent investing, ambition, why we don’t have more Thiel Fellowships, his new focus on AI, and AI safety concerns.

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(00:59) Talent matters most (03:17) Scarcity of talent x culture (09:16) Founder qualities: effectiveness, unlocking resources (14:37) Can you teach ambition? (16:44) Failure to learn is an anti-signal (19:13) Alternative funding: income share agreements, adverse selection, longer term bets, & government funding (27:11) Why don't we have more grant programs or patrons, like the Thiel Fellowship? Scaling taste in talent & the macro talent allocation problem (41:32) Focusing on AI & handing off the EF CEO role (47:00) Is AI safety futile? Threat models and radical uncertainty (53:31) Final question for listeners

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Matt’s Twitter: https://twitter.com/matthewclifford

Entrepreneur First: https://www.joinef.com/

Personal Site: https://www.matthewclifford.com/

Spencer’s Twitter: https://twitter.com/SP1NS1R

Spencer’s Blog: https://spencerkier.substack.com