9min chapter

Plain English with Derek Thompson cover image

Fraud, Scandal, and Failure in the Fight Against Alzheimer's Disease

Plain English with Derek Thompson

CHAPTER

The Evolving Amyloid Hypothesis

This chapter explores the historical development and impact of the amyloid hypothesis in Alzheimer’s research, tracing its origins from 1906 through the pivotal studies and funding that shaped its prominence. It highlights key studies, including a 2006 discovery that redefined the understanding of amyloid beta and its relationship to memory loss. Despite substantial support for this leading theory, the narrative scrutinizes its limitations and the complexities in correlating amyloid presence with cognitive symptoms.

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